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$-16\left(x^2-4\right)^2+2216x^2\left(x^2-4\right)$
Learn how to solve product rule of differentiation problems step by step online. Find the derivative using the product rule -16(x^2-4)^2+2216x(x^2-4)x. Simplifying. Solve the product 2216x^2\left(x^2-4\right). Multiply 2216 times -4. When multiplying two powers that have the same base (x^2), you can add the exponents.